ceesdekker.net for Dummies
ceesdekker.net for Dummies
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Midway via his job, Cees Dekker reinvented himself. Right after decades of hardcore physics, he shifted his target to ‘nanobiology’ within the change of your millennium. A expression he coined himself, as a subject of fact.
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‘It absolutely was basically a make a difference of picking up a reserve on mobile biology and starting to read. I'd originate from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was working at place temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
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Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
‘Initially we looked at Organic units having a Bodily watch and acted on the basis in the instruments we knew. It took a couple of years in advance of we begun Operating far more on the massive Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at some time.
2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
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There was just one trouble though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these good conductors, which was alternatively disappointing. We thus broadened our see to try to locate a lot more promising molecules.
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and determined about 5 hundred genes which are minimally expected for a performing cell. We want to glance bottom-up: how do we go from the couple of molecules to a whole Organic system?
Developments in nanotechnology while in the nineties designed making Digital equipment from one molecules a risk. Cees Dekker recounts how his workforce established a home-temperature transistor based on a single carbon cees dekker nanotube.
2004, discovery of new physics in translocation of DNA by nanopores; 1st experimental analyze of ions conduction in nanofluidic channels; first electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and initially single-molecule analyze of DNA translocation by a restriction-modification enzyme.